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MEG/EEG Real-Time Source Localization

Project description


Providing millisecond-temporal resolution for non-invasive mapping of human brain functions, Magnetoencephalography (MEG) and Electroencephalography (EEG) are optimal to monitor brain activity in real-time. Real-time feedback allows the adaption of the experiment to the subject’s reaction creating a whole set of new options: it could accelerate the rehabilitation of stroke patients, improve the adaption of neuroimplants, accelerate diagnostic procedures, and it could increase the classification rate of brain computer interfaces (BCIs).

Together with scientists of the Athinoula A. Martinos Center for Biomedical Imaging (Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, United States) scientists of the Technische Universität Ilmenau focus on the research and development of real-time brain monitoring solutions. Source localization algorithms are parallelized and optimized utilizing the graphics processing units (GPUs) and NVIDIAs Compute Unified Device Architecture (CUDA). The developed software framework and the algorithm library are open source and publicly available (MNE-CPP).

Publications & patents


  • Dinh, C.; Rühle, J.; Bollmann, S.; Haueisen, J.; Güllmar, D.: A GPU-accelerated Performance Optimized RAP-MUSIC Algorithm for Real-Time Source Localization. In Biomedizinische Technik (Berl.), 2012, 57
  • Dinh, C.; Strohmeier, D.; Haueisen, J.; Güllmar, D.: Brain Atlas based Region of Interest Selection for Real-Time Source Localization using K-Means Lead Field Clustering and RAP-MUSIC. In Biomedizinische Technik (Berl.), 2012, 57


  • Güllmar, D.; Dinh, C.; Graichen, U.; Reichenbach, J. R.; Haueisen, J.: Accelerated brain‐state segmentation using Laplacian Eigenspace Operator. In 18th Conference on Biomagnetism (2012)
  • Dinh, C.; Rühle, J; Bollmann, S.; Haueisen, J.; Güllmar, D.: Ein GPU-beschleunigter und Berechnungsoptimierter RAP-MUSIC Algorithmus zur Online-Quellenlokalisation. In bbs2012 (2012)
  • Dinh, C.; Bollmann, S.; Eichardt, R.; Baumgarten, D.; Haueisen, J.: A Performance-Optimized RAP-MUSIC-Algorithm for Online Source Localizations. In OIPE (2010)