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Gaze controlled stimulation

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Project description

The examination of the visual field – the perimetry – is one of the most important methods for early diagnosis of glaucoma and other eye disorders. Conventional treatments require an active cooperation of the patient. This refers to the ability as well as to the will to fix a defined point in the visual field and to signalise the perception of a light stimulus. If these preconditions are not fulfilled than a visual field testing can only carried out with patient independent methods. It is known, that stimulus perception can be clinical detected by the means of the EEG. The signal parts in the EEG that are cause by stimulation of the visual system are named visual evoked potentials. At previous examinations it was necessary that the patient fixes on one point during the complete testing. This is very exhausting. For this reason the stimuli is supposed to track the current line of vision. Newly developed pseudo-random sequences are used as stimuli. The stimulation occurs multifocal, i.e. at various retinal places simultaneous, to reduce the examination time to a reasonable extend.

Figure 1:  Digital stimulation system for gaze controlled stimulation.

Publications & patents

Publications:

  • Klee S, Link D, Bessler P, Haueisen J.: Optoelectrophysiological stimulation of the human eye using fundus-controlled silent substitution technique. Journal of Biomedical Optics 16(1): 015002, 2011
  • Link, D., Strohmaier, C., Seifert, B.U., Riemer, T., Reitsamer, H.A., Haueisen, J., Vilser,  W.: A novel non-contact retina camera for the rat and its application to dynamic retinal vessel analysis. Biomedical Optics Express, 2(11):3094–3108, 2011
  • Bessler P, Klee S, Kellner U, Haueisen J.: Silent Substitution Stimulation of S-cone pathway and L- and M-cone pathway in glaucoma. Investigative Ophthalmology & Visual Science, 51(1):319-26, 2010
  • Klee, S., Bessler, P., & Haueisen, J. (2010). Characterization and application of an optoelectrophysiological color stimulator. In 55th IWK – Internationales Wissenschaftliches Kolloquium Ilmenau: Ilmenau University of Technology.
  • Klee, S., Link, D., Bessler, P., & Haueisen, J. (2009). Fundus Controlled Silent Substitution of the Human Eye. In O. Dössel & W. C. Schlegel (Eds.), 11th International Congress of the IUPESM. Medical Physics and Biomedical Engineering. World Congress 2009. Biomedical Engineering for Audiology, Ophthalmology, Emergency & Dental Medicine (pp. 219-222). Heidelberg: Springer Verlag, Berlin, Germany.
  • Klee, S., Link, D., Bessler, P., & Haueisen, J. (2010). Application of a fundus-controlled color stimulator for selective cone excitation. In G. K. Lang & S. J. Ryan (Eds.), 17th International Congress of Ophthalmology, 108th DOG Congress, WOC 2010 (pp. P-SA-145-4193). Berlin.
  • Link, D., Klee, S., Seifert, B. U., & Haueisen, J. (2009). Digital Color Stimulator for Vision Research. In O. Dössel & W. C. Schlegel (Eds.), World Congress on Medical Physics and Biomedical Engineering 2009 (pp. 231-234). Heidelberg: Springer.
  • Link, D., Klee, S., Seifert, B. U., & Haueisen, J. (2010). Color stimulator for electrophysiological investigations in the human eye. In G. K. Lang & S. J. Ryan (Eds.), 17th International Congress of Ophthalmology, 108th DOG Congress, WOC 2010 (pp. P-SA-147-4193). Berlin.
  • Link, D., Klee, S., Seifert, B. U., & Haueisen, J. (2010). Farbstimulator für die elektrophysiologische Diagnostik am Auge. In 111. Jahrestagung der deutschen Gesellschaft für angewandte Optik e.V. Wetzlar.