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Institutskolloquium der Physik und Chemie: "Towards sustainable biotechnology: combining light-driven catalysis and synthetic biology"

Die Hochschullehrer der Institute für Physik und Chemie der TU Ilmenau laden am Dienstag, dem 14. Januar 2020, zu einem gemeinsamen Kolloquium der Physik und Chemie ein.

Es spricht um 17:15 Uhr im Faraday-Hörsaal Prof. Dr. Julie Zedler vom Matthias-Schleiden-Institut der FSU Jena zum Thema ""Towards sustainable biotechnology: combining light-driven catalysis and synthetic biology"".

Zum Vortrag:

One of the biggest current societal challenges is to develop a sustainable bioeconomy and reduceour dependency on finite natural resources. To address this challenge, it is crucial to develop solutions for transforming solar light energy, inorganic CO2 and nutrients into bioavailable, organic products. In nature, this conversion is carried out routinely by photosynthetic organisms – sunlight is converted into chemical energy and utilised to fix inorganic CO2 into organic carbon skeletons. Utilising and expanding the capacity of these organisms will be crucial for our future bioeconomy.

We have previously shown that photosynthetic energy can be utilised to directly fuel recombinant redox enzymes. This technology is of major interest to the sustainable biotechnology sector, however, technical and biological limitations will have to be overcome to achieve scalable systems.

Now we are focusing on using synthetic biology approaches to improve cyanobacterial cell factories. Our goal is to engineer designated locations and compartments for product synthesis within the cell. To achieve this, we are engineering cytoplasmic protein-based structures serving as a scaffold for enzymes of a biosynthetic pathway. We have expressed a structural scaffold protein in two different cyanobacterial species: the widely used model organismSynechocystis sp. PCC 6803 and a recently described, fast growing cyanobacterium Synechococcus elongatus UTEX 2973. Our preliminary results are promising showing intracellular, de novo structures formed in vivo. In thispresentation implications of this technology for the next generation of cyanobacterial cell factories will be discussed.