Compartmentalized microarrays as a new multiplex PLUS diagnostic platform for the fast and reliable detection of Lyme disease

Contact person

Prof. Andreas Schober
Nano-Biosystems Engineering Group

Phone: +49 3677 69-3387

Funding information

Project leader: AIF Projekt GmbH Berlin

Project number:  ZF4457305AP9

Participating groups: Nano-Biosystems Engineering Group

Period of funding:  01.12.2019 - 31.05.2022

Project information

The project goal is the development of a new multiplex platform, which for the first time enables comprehensive, sensitive and standardizable Lyme disease diagnostics. Due to the characteristics of tick-borne borrelia (five species; high antigen-numberZ variability), no test is yet available that clearly detects the multisystemic disease, which tends to chronicle without therapy. The development of a novel micro-compartmentalized carrier, an application method for single tests as well as a time-resolved fluorescence detection will allow an unprecedented number of parallel tests, which will allow a reliable diagnosis of Borrelia bacteria and, among other things, statements on the stage of the disease and a differential diagnosis. Furthermore, for the first time it will be possible to present whole Borrelia cells as target for antibody detection in the microcompartments. Due to the strong increase in the number of cases and the great medical and health political importance, there is a great demand in the international market for performance-enhanced, easy-to-perform diagnostics, so that a successful, sustainable marketing of the new assay is expected.