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Marco Frezzella


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Institutskolloquium der Physik und Chemie

Die Hochschullehrer der Institute für Physik und Chemie der TU Ilmenau laden am Dienstag, dem 15. Januar, zu einem gemeinsamen Kolloquium der Physik und Chemie ein. Es spricht um 17:15 Uhr im Faraday-Hörsaal Dr. Stefan Schiller vom Freiburg Institute for Advanced Studies (FIAS) der Albert-Ludwigs-Universität Freiburg zum Thema „Modular Molecular protein tectons enabling complex functional systems: From mecanichal metamaterials and compartmentalized biotechnology to a potential prebiotic protein world constituting protocells".

Zum Vortrag:

Our research approach towards complex functional systems and materials is based on the design and (bio)synthesis of defined and selectively chemically modified multifunctional molecular protein building blocks with specific structural and functional properties. Due to the control of 3D structure and the exact position of functional moieties we termed them molecular tectons (architectural building blocks at molecular dimensions) providing a powerful basis for the assembly of large and dynamic 3D objects and materials. The environmental control of structure/conformation of the specific fold/sequence design derived from structural protein sequences e.g. elastic-like proteins (ELP) allows to „program“ responsive and adaptive molecular systems constituting defined compartmentalized reaction spaces in vitro and in vivo and materials with superior responsive properties. Currently we advance our biomolecular material systems by combining our ultraelastic protein-based materials with advanced 3D structuring via stereolithography towards ultraelastic biobased materials with mechanical metamaterial properties. Due to the stimulus responsive character of these material systems we facilitated our research towards autonomous material machines. In addition biomimetic proteins with block-domain character allow for the self-organization of vesicular structures in vitro and in vivo. The dynamic membrane character allows them to be employed as de novo organelles for the compartmentalization of reaction spaces in prokaryotes otherwise deficient of dynamic organelles for the biofermentation of ultrapotent drugs/enzymes. Furthermore dynamically adaptive, protein-based organelles (PBOs) allow to constitute a first example for simple prebiotic protocells based on proteins only! They also show a promising potential for in vitro compartmentalization of biotechnological processes due to their extreme possible stability window up to 100 °C, pH between 2 and 13 and higher ionic strengt. Finally, we demonstrate new pathways towards prebiotic protocells which demonstrate autopoieses with compartmentalization and anabolic reactions being based on one class of molecules - proteins.