Doris Heinrich leitet seit Ende 2020 das neu berufene Fachgebiet "Biotechnische Mikro- und Nanosysteme für die Lebenswissenschaften". Ihr Forschungsschwerpunkt liegt auf der Biophysik von Zellen. Zu den untersuchten Systemen gehören molekulare Motoren, die Effekte externer Reize auf Zellen, die Dynamik der Zelladhäsion und -migration sowie  intrazelluläre Transportprozesse.

Sie schloss ihr Studium mit einem Master in Physik (Thema: Near-field Scanning Optical Microscopy of Semiconductor Nanostructures) an der University of Texas at Austin/ USA ab und promovierte in Halbleiterphysik (Thema: Optisch induzierte Ladungsspeicherung in selbstgebauten Semiconductor Quantum Dots) an der Technischen Universität München. Anschließend forschte sie in München, Los Angeles und Heidelberg bei Prof. Dr. E. Sackmann und untersuchte die mechanischen Eigenschaften des Mikrotubuli-/Aktin-Cross-Talks lebender Zellen.

Danach arbeitete sie als Unternehmensberaterin bei McKinsey & Company bei verschiedenen Projekten in Frankreich, dem Nahen Osten und den USA. 2007 gründete sie eine eigene Forschungsgruppe an der Ludwig-Maximilians-Universität München (LMU). Von Februar 2013 bis September 2020 war sie Professorin an der Universität Leiden (NL). Seit Februar 2019 leitet sie das Fraunhofer Zentrum „3DNanoCell“ am Fraunhofer ISC in Würzburg. Seit Oktober 2020 leitet sie auch als Institutsdirektorin das Institut für Bioprozess- und Analysenmesstechnik e.V. (iba) in Heilbad Heiligenstadt, ein An-Institut der TU Ilmenau.

 

Professionelle und wissenschaftliche Erfahrung

Seit 2020:   Institutsdirektorin des Instituts für Bioprozess- und Analysenmesstechnik e.V. (iba) in Heilbad Heiligenstadt

Seit 2019:   Leiterin des Fraunhofer Zentrums „3DNanoCell“ am Fraunhofer ISC in Würzburg

2013-2020:   Professur für Biophysik an der Universität Leiden, LION, Institut für Physik

2007 - 2013:   Zellbiophysik-Gruppenleiter an der LMU München, Deutschland

2006 - 2007:   Unternehmensberater bei McKinsey & Company

2003 - 2005:   Postdoc in Biophysik an der TU München, Uni Heidelberg und UCLA, USA

April 2003:   Ph.D. (Dr. rer. nat.) in Halbleiterphysik an der TU München (WSI), Deutschland

 

Preise, Auszeichnungen, Stipendien

2017   Paper of the Year Award (Biophysical Journal)

2015   ERC Consolidator Grant

2013   Fraunhofer Attract Grant

2011   CeNS Publication Award

2007   Science Career Fellowship

2004-2005   Academics & Science Program (HWP II) Postdoc Fellowship

2004   BaCaTec Visiting Fellowship Stipendium

2004   Minerva Foundation Grant

2002   Academics & Science Program (HWP I) Promotionsstipendium

1997   Honor Society Mitgliedschaft von "Phi Kappa Phi" (Austin, TX/USA) aufgrund GPA von 4.0

1995   Deutsches Akademisches Austauschprogramm (DAAD) Stipendium für Studienaufenthalte in den USA

 

Invited Talks (Auswahl)

 
  • Metal-Cluster-DNA for Advanced Biosensing Applications”, BIOCEV Workshop, 16.05.2019, Vestec/Prague, Czech Republic
  • Cell Dynamics – from insight to control”, Cell Observatory Workshop at Leiden University, 12.12.2018, Leiden (NL)
  • “Cell Dynamics in Controlled Micro-Environments” 10.10.2018 Workshop on Mathematical Modelling of Biological Processes, Centro di Ricerca Matematica Ennio De Giorgi, 08.10.2018-12.10.2018, Pisa (I)
  • “Influence of Material Surfaces on Cell Motility” 14.06. 2018, International Conference on Coatings on Glass and Plastics ICCG 2018, 12.6. – 14.6.2018, Würzburg (D)
  • “3D Scaffolds for Controlled Cell Migration and Tissue Engineering”, 24.01.2018, NanoMat Workshop, KIT, Karlsruhe (D)
  • „Functionalised Surfaces and 3D Scaffolds for Controlled Cell Adhesion, Migration and Tissue Engineering”, Maastricht Topo-Chip Seminar, 08.01.2018, Maastricht (NL)
  • “Should I stay or should I go? Bottom-up designed 3D Scaffolds for Controlled Cell Migration and Tissue Engineering” 29.11. 2017, Annual Meeting of the Dutch Society for Biomaterials and Tissue Engineering NBTE, Lunteren, (NL)
  • “Nanostructured 3D Scaffolds for Controlled Cell adhesion and Tissue Endgineering”14.-15.10.2017 Fraunhofer Workshop on „Nanomaterials in Harsh Environments“ Bremen (D)
  •  “Dynamics of the Cellular Interior – from insight to control”, 18.-23.9.2017 „Conference on Complex Systems in LifeScience“, St. Petersburg (Russia)
  • Cell Dynamics in Complex Environments”, 07.04.2017 PHYSICA Groningen (NL)
  • Controlled Cell Migration in Complex, Multi-Cue Environments” 3.-5.5.2017 CECAM Workshop „Cell and Tissue Motility“, Lausanne (CH)
  • TPA-microstructured ORMOCER- Composites”, 01.03.2017 Seminar Talk KIT Karlsruhe (D)
  • “Cellular Dynamics going from intracellular transport to controlled cell migration”, 25.01.2017, Lecture at the Winter School in  Han-sur-Lesse (B)
  •  “Cell Dynamics – from intracellular transport to controlled cell migration” Colloquium talk, 15.9.2016 TU Eindhoven (NL)
  • “Tracer size dependent anomalous transport in living cells” at Mini-colloquium “Anomalous transport in crowded cells and soft matter” at the “CMD 26- Condensed Matter” 6.-9.9.2016 in Groningen (NL)
  • „Control of Cell Functions by Mechano-Chemical Cues“, TransRegio-SFB-Colloquium, 13.7.16, University of Gießen (D)
  • „Dynamic Force Field Mapping of Living Cells in a Macro-Scale Transducer Array based on Flexible Semiconductor Nanopillars", 3rd International Symposium on "Integration of Molecular Components in Functional Macroscopic Systems”, Volkswagen-Foundation, 2.- 4.5.2016, Hannover (D)
  • „3DNanoZell: Zellbasierte Assays auf 3D-bottom-up-nanostrukturierten Oberflächen“, 23./24.2.16 Fraunhofer Netzwert Symposium, Munich (D)
  • „Wechselwirkung von biologischen Zellen mit dreidimensionalen (Nano-) Oberflächen“, 21.1.16 Materials-Valley Symposium at Heraeus Holding GmbH in Hanau (D)
  • “Guiding cells towards Regeneration”, 24.10.15 Invited talk at Alumni Meeting LION, Leiden University, Leiden (NL)
  • “Biomaterials for life-cell applications”, 1.10.2015, TechTalk Biomaterials, Lorentz Center , Leiden University, Leiden (NL)
  •  “Controlling Cellular Dynamics by External Cues”, 28.9.15, Invited talk at Dutch Biophysics Meeting in Veldhoven (NL)
  • “Control of Cell Dynamics by External Cues”, 9. 6.15 Invited seminar talk at Max-Planck-Institute and University of Göttingen (D)
  • “Spatio-temporal Control of Cell Dynamics”, 13.4.15 Invited seminar talk at AMOLF, Amsterdam (NL)
  • “Dynamics in living cells – from intracellular information transport to cell migration in complex environments”, 1st Nanofront Winter-Retreat, March 2015, Courchevel, (France)
  •  “BIOPHYSICS, Bridging the distance between the complexity of life and the simplicity of physical laws”, LION Physics Ladies Day, Leiden University, 31.10.2014, Leiden (NL)
  • “Fraunhofer Attract 3D NanoCell – Combining physics and life science”, Fraunhofer Kuratorium at ISC, 23.10.2014, Würzburg (D)
  • Spatio-temporal cues to control cell dynamics”,  Fraunhofer Sol-Gel Fachkonferenz, 21./22.10.2014, Würzburg (D)
  • “Fluctuations in Living Cell Dynamics”, 12.10.14, International Conference: “Venice Meeting on fluctuations in small complex systems”, Venice (Italy)
  • “Perspectives of Sol-Gel Technology for Surfaces with Tunable Cell Interactions”, 22.10.14, Fraunhofer Sol-Gel Conference, ISC Würzburg, (D)
  • “Chemotaxis, Cell Shape Changes, and Intracellular Transport Phenomena – An Integrated Story”, 04.09.14, International Conference “Physics meets Biology 2014”, Oxford (UK)
  • “Intracellular Transport Phenomena addressed by Single Particle Tracking and Local Mean Squared Displacement Analysis”, 26.8.14, European Condensed Matter Physics Conference (CMD25), Paris (France)
  • “Cellular Kinetics - from intracellular transport to cell migration”, 02.07.14, “Reaction Kinetics in Soft and Condensed Matter RKCM 2014”, Orleans (France)
  • “Living Cell Dynamics - from intracellular transport to cell migration”, 14.6.14, “Self-propelled Particles”-Conference, Bad Honnef (D)
  • “Advanced Microfluidics for Control of Living Cells”, 06.02.14, “Prof meets CEO”-meeting, Leiden BioScience Park, Leiden (NL)
  • “Dynamic force field mapping of living cells in a macro-scale transducer array based on flexible semiconductor nanopillars”, 13.1.14, 2nd International Symposium on "Integration of Molecular Components in Functional Macroscopic Systems”, Volkswagen-Foundation, Hannover (D)
  •  “Dynamics of cellular nano-architecture in spatio-temporally controlled environments”                                                              Biophysical and Biomedical Technology Meeting, November 2013, Amsterdam (NL)
  •  “Cell-based Assays on 3D-nanostructured Surfaces for Regenerative Medicine” Medical Seminar  at the Universitätsklinikum Würzburg , October 2013, Würzburg (D)
  •  “Cellular Dynamics and Nano-architecture for Biomedical Applications” LION Discovery Day, June 2013, Doorn (NL)
  •  “Cellular Migration Strategies in 3D-Structured Environments” Casimir-Research School Symposium `Science Day´, June 2013, Leiden (NL)
  •  “Cells under external stimuli: Chemotactic cell control in spatio-temporally alternating gradient fields” Imperial College, Seminar, December 2012, London (UK)
  •  “Dynamics and Control of  Cellular Nanoarchitecture” Cell Microscopy Workshop, October 2012, University of Bayreuth (Germany)
  • Controlling Cell Migration by External Stimuli” International Workshop “Cancer Cells On-Chip”, June 2012, University of Lyon (France)
  • Control and Functions of Cellular Nanoarchitecture” Symposium at the University of Cologne, February 2012, Cologne (D)
  • Impact of Cellular Nanoarchitecture on Function-Control in Living Cells” Physics Seminar, University Würzburg, February 2012, Würzburg (D)
  • Dynamics and Control of Cellular Nanoarchitecture” Symposium at the University of Tübingen, December 2011, Tübingen (D)
  • Cell Dynamics and Cellular Function Control” Professor Selection Seminar, LION, Leiden University, September 2011, Leiden (NL)
  • Controlling cell migration by spatio-temporally defined microfluidics” Colloquium of the Dutch National Academy of Science, September 2011, Amsterdam (NL)
  • Investigating the Dynamics of Cellular Nano-Architecture to Control Cell Functions” Symposium at the University of Erlangen, September 2011, Erlangen (D)
  • Dynamic Polymer Systems – from Cellular Nano-Architecture to Force Sensor Arrays” Symposium at the University of Würzburg, July 2011, Würzburg (D)
  • Probing Intracellular Feedback by Advanced Microfluidics” Colloquium of the Graduiertenkolleg, July 2011, Saarbrücken (D)
  • Controlling Cell Migration Strategies by External Cues” Physikalisches Kolloquium, July 2011, Erlangen (D)
  • Probing PI3-kinase and Phospholipase A2-based Feedback with Ongoing Starvation of  Cells” Short talk at the Gordon Conference on “Gradient sensing and directed cell migration”,June 2011, Les Diablerets (Switzerland)
  • “Motion Analysis Applied to Living Cells - from intracellular transport to cellular migration strategies” Symposium TU Chemnitz, February 2011, Chemnitz (D)
  • „Dynamic Nanoarchitecture in Living Cells“ Symposium at the University of Münster, April 2011, Münster (D)
  • Motion States in Intracellular Transport” Topical Talk at DPG-Springmeeting (Deutsche Physikalische Gesellschaft), March 2011, Dresden (D)
  • Spatio-Temporally Controlled Cell Migration” Eugene-Wigner-Colloquium of the Graduiertenkolleg 1558 and the SFB 910, February 2011, Berlin (D)
  • „Dynamic Properties of the Cellular Micro- and Nanoarchitecture – from intracellular transport to celllular migration strategies“ Symposium at the BIOTEC /TU Dresden, January 2011, Dresden (D)
  • Physics in Living Cells: Intracellular Transport and Cellular Migration” Physikerinnentagung of the Deutsche Physikalische Gesellschaft, November 2010, München (D)
  • Intracellular Transport Phenomena and Cellular Migration Processes ” University Lyon, Biophysics-Seminar, Prof. Jean-Paul Rieu, May 2010, Lyon (France)
  • Influences of Cellular Nano-Architecture on Transport Phenomena in Living Cells and Organisms” International Workshop on “Molecular Motors, Tracks & Transport”,January 2010, Pondicherry (India)
 

Internationale Konferenzen (Auswahl):

 
  • D. Heinrich “Influence of Material Surfaces on Cell Motility” 14.06. 2018, International Conference on Coatings on Glass and Plastics ICCG 2018, 12.6. – 14.6.2018, Würzburg, Germany
  • D. Heinrich “Tracer size dependent anomalous transport in living cells” (Invited Talk)in Mini-colloquium “Anomalous transport in crowded cells and soft matter” at the “CMD 26- Condensed Matter”6.-9.9.2016 in Groningen, NL
  • German Physical Society Meeting “Tag der Physik” as Council member and price committee member, 10./11.11.2016 in Bad Honnef, Germany
  • D. Heinrich “Cell Migration in complex environments”, Dictyostelium discoideum meeting December 2015 in Göttingen, Germany
  • D. Heinrich “Cell migration in complex environments and intracellular sensor dynamics” (Posters), Physics of Cells 2015, 31.8.-4.9.2015, Kloster Banz, Bad Staffelstein, Germany
  • D. Heinrich “Controlling Cellular Dynamics by External Cues”, 28.9.15, Invited talk at Dutch Biophysics Meeting in Veldhoven, NL
  • German Physical Society Meeting “Tag der Physik” as Council member and price committee member, 13./14. November 2015 in Bad Honnef, Germany
  • D. Heinrich “Dynamics in living cells – from intracellular information transport to cell migration in complex environments” (invited talk), 1st Nanofront Winter-Retreat, March 2015, Courchevel, France
  • German Physical Society Meeting “Tag der Physik” as Council member and price committee member, November 2014 in Bad Honnef, Germany
  • D. Heinrich “Dynamic force field mapping of living cells in a macro-scale transducer array based on flexible semiconductor nanopillars”,(Poster), 2nd International Symposium on "Integration of Molecular Components in Functional Macroscopic Systems”, Volkswagen-Foundation, 13.1.14, Hannover, Germany
  • D. Heinrich PI3-Kinase Based Cell Repolarization Mechanisms in Spatio-Temporally Varying Chemotactic Gradient Fields(Talk), Annual meeting of the German Biophysical Society 2012, Göttingen,Germany
  • D. Heinrich “Probing PI3-Kinase based feedback in alternating chemotactic gradient fields with ongoing cell starvation time” (Talk), Annual International Dictyostelium Conference DICTY 2012, Madrid, Spain
  • D. Heinrich, “Spatio-temporally controlled actin polymerisation and pattern formation in living cells” (Talk), CellMech – Cell Mechanics Meeting 2011, Amsterdam, Netherlands
  • B. Meier, D. Heinrich, “Spatio-temporally alternating gradient fields for chemotactic cell control”        (Talk + Poster) Gordon Conference on “Gradient sensing and directed cell migration” 2011, Les Diablerets, Switzerland
  • D. HeinrichDynamic Nano-Architecture in Living Cells: from intracellular transport to cell migration strategies” (Poster) NanoBioMeeting 2011, Singapore
  • D. Heinrich, “Cell motility in surface-structured environments” (Talk), International Dictyostelium Conference DICTY2010, Cardiff, UK