INSTITUTSKOLLOQUIUM
des Instituts für Chemie und Biotechnik
Am Mittwoch, den 6. Mai 2026, spricht um 15:00Uhr im Curie-Hörsaal,
Herr Prof. Dr. Danny Porath
Institut of Chemistry
Center for Nanoscience and Nanotechnology and Casali Center for Applied Chemistry
The Hebrew University of Jerusalem, Israel
zum Thema: „Charge Transport in DNA: From Fundamental Insights to Ultra-Sensitive Detection“
Abstract:
The ability to recognize and manipulate the DNA double helix opens new opportunities for molecular electronics. Our recent work (Nature Nanotechnology, 2020) demonstrated a breakthrough in measuring charge transport in DNA in a unique nanoscale configuration. This discovery is not only fundamental for understanding electrical properties in DNA but also holds broad implications for molecular electronics.
Beyond its fundamental scientific value, this insight lays the foundation for the development of ultra-sensitive, label-free DNA and RNA detection methods. Such advancements are particularly crucial for early cancer diagnosis, pathogen identification, emergency medicine, and pandemic preparedness, as seen in the case of COVID-19.
In this seminar, I will present our approach to probing charge transport in DNA and discuss how we are leveraging this phenomenon for next-generation molecular detection technologies.
References
[1] "Direct measurement of electrical transport through DNA molecules", Danny Porath, Alexey Bezryadin, Simon de Vries and Cees Dekker, Nature 403, 635 (2000).
[2] "Charge Transport in DNA-based Devices", Danny Porath, Rosa Di Felice and Gianaurelio Cuniberti, Topics in Current Chemistry Vol. 237, pp. 183-228 Ed. Gary Shuster. Springer Verlag, 2004.
[3] "Long-range charge transport in single G4-DNA molecules", Gideon I. Livshits et. al., Nature Nanotechnology 9, 1040 (2014).
[4] “Advances in Synthesis and Measurement of Charge Transport in DNA-Based Derivatives”. R. Zhuravel, A. Stern, N. Fardian‐Melamed, G. Eidelshtein, L. Katrivas, D. Rotem, A. Kotlyar and D. Porath, Advanced Materials 30, 1706984 (2018).
[5] "Backbone charge transport in double-stranded DNA", R. Zhuravel et. al., Nature Nanotechnology, 15(10), 836 (2020).
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