Research Group Microfluid Biotechnique

Nachwuchsgruppenleiterin / Head of Research Group

Dr. rer. nat. Jialan Cao-Riehmer

Visiting address:
Prof. Schmidt Str. 26 Heliosbau Room 1104
98693 Ilmenau

Mail address:
Postfach 10 05 65
98684 Ilmenau

E-Mail: Jialan.Cao@tu-ilmenau.de

+49 (0) 3677 69-3657

Forschung / Research focus

The Microfluid Biotechnique Research Group is focused on the development of microfluid devices, sensors and optimization of microfluid screening processes, cultivation and characterization of

Soil Microorganisms,
Photosynthesis-active microorganisms (cyanobacterium, algae) and
Plant cell cultures (microspores, protoplasts)

J. Cao-Riehmer

Team

M. Sc. Linda Ehrhardt (PhD Student)

Linda Ehrhardt

+49 3677 69-3672

Forschungsgebiet: Mikrofluidtechnik für die Untersuchung von Bodenmikroorganismengemeinschaften

Research area: microfluidic technology for the study of the soil microbial communities

M. Sc. Ting Xie (PhD student)

Ting Xie

+49 3677 69-3715

Forschungsgebiet: Entwicklung eines mikrofluidischen Systems für die Selektion und Anwendung bioelektrochemisch aktiver Bodenbakterien für die CO₂-Fixierung

Research focus: Development of a microfluidic system for the selection and application of bioelectrochemically active microorganisms for CO₂ fixation

M. Sc. Paulina Marczakiewicz-Perera (PhD Student)

Paulina Marczakiewicz-Perera

+49 3677 69-3689

Forschungsgebiet: Anwendung der Mikrofluidtechnik für die Pflanzenbiotechnologie

Research focus: Application of microfluid technology for plant cells: The goal of her research is to optimize a microfluid platform for cultivation of various plant cell cultures, such as protoplasts and somatic cells. Subsequently, she investigate effect of external factors (growth regulators, salts content, light etc.) on the early divisions at nearly single cell level.

Baean Nasr (Master student)

Baean Nasr

+49 3677 69-3715

Masterarbeit: Dosis-Wirkungsscreening von Pseudomonas Putida KT2440 gegen leichte und schwere Lanthanide und Entwicklung eines Protokolls für die Segment-RNAseq-basierte Genexpressionsanalyse

Research focus: Dose-response screening of Pseudomonas putida KT2440 in response to light and heavy lanthanides and library preparation for Droplet RNAseq-based gene expression analysis

Alumi

Frau Nadia Davina Prasetija

Masterarbeit: Untersuchung des Wachstums und der Sensitivität von Mikroalgen und Cyanobakterien gegen Effektoren unter verschiedenen Lichtkonditionen in mikrofluidischen Photobioreaktoren (µPBR)

Herr Felix Richter

Masterarbeit: Einsatz der Mikrofluidsegmenttechnik zur Untersuchung der Pflanzenembryogenese am Beispiel von Brassica napus

Frau Nadhrah Musfira

Bachelorarbeit: Characterization of Microfluidic Devices for the Generation of multidimensional Concentration Space and for the Investigation of Growth of Cyanobacteria

Our paper and artwork has been selected as cover for Journal Lab on a Chip

Induction of embryogenic development in haploid microspore stem cells in droplet-based microfluidics

In a recently published study, together with University Freiburg, TU Ilmenau and Company ScreenSys, we did studies of droplet-based microfluidics for application in plant cells. Here, we present our droplet-based tube system suitable for implementation in an automated, miniaturized system with a microchannel as the central transport and processing unit to achieve induction of embryogenic development in haploid stem cells.

Link: xlink.rsc.org

http://xlink.rsc.org/?DOI=D2LC00788F

Publikationen / publication

T. Xie, L. Ehrhardt, P.M. Günther, J.M. Köhler and J. Cao*„Current to Biomass: Media Optimization and Strain Selection from Cathode-Associated Microbial Communities in a Two-Chamber Electro-Cultivation Reactor” environments 2023, 10,97.doi.org/10.3390/environments10060097
T. Xie, J.M. Köhler, S. Heyder, P.M. Günther and J. Cao*„Microfluidically-assisted Isolation and Characterization of Achromobacter spanius from Soils for Microbial Degradation of Synthetic Polymers and Organic Solvents” environments 2022, 9(12), 147doi.org/10.3390/environments9120147
F. Richter, M. Chen, P. Schaub, F. Wüst, D. Zhang, S. Schneider, G. A. Groß, P. Mäder, O. Dovzhenko, K. Palme, J. M. Köhlerund J. Cao*„Induction of embryogenic development in haploid microspore stem cells in droplet-based microfluidics” Lab Chip 2022,https://doi.org/10.1039/D2LC00788F
J. Cao*, U. Pliquett, L. Yang, S. Wiedemeier, B. Cahill and J. M. Köhler „Contactless Optical and Impedimetric Sensing for Droplet-based Dose-response Investigations of Microorganisms” Sensors and Actuators B: Chemical 2022, 132688 https://doi.org/10.1016/j.snb.2022.132688
J. Cao, C. Chande and J. M. Köhler „Microtoxicology by Microfluidic Instrumentation: a review” invited review lab Chip 2022, https://doi.org/10.1039/D2LC00268J
J. Cao, D. Russo, T. Xie, G.A. Groß and J. Zedler „A droplet-based microfluidic platform enables high-throughput combinatorial optimization of cyanobacterial cultivation” Scientific Reports 2022, 12,15536 https://doi.org/10.1038/s41598-022-19773-6
J. Cao, C. Chande, F. Kalensee, T. Schüler, M Köhler, „Microfluidically supported characterization of responses of R. erythropolis strains isolated from different soils on Cu-, Ni-, and Co-Stress” Brazilian Jour. of Microbiol 2021,52, 1405-1415 https://doi.org/10.1007/s42770-021-00495-2
J. Cao, F. Richter, M. Kastl. et al. „Droplet-based screening for the investigation of microbial nonlinear dose-response characteristics system, background, and examples” Micromachines 2020, 6, 557, doi.org/10.3390/mi11060577
J. Cao, T. Schüler, J. M. Köhler. „Stochastically reduced communities—Microfluidic compartments as model and investigation tool for soil microorganism growth in structured spaces”, Journal Eng. Life Science, 2017, 17, 792-800, DOI:10.1002/elsc.201600264
J. Cao, S. Nagl, E. Kothe and J.M. Köhler, “Oxygen sensor microparticles for monitoring bacterial growth and characterization of dose/response functions in microfluidic screenings”, Microchim Acta, 2015, 182, 385-394, DOI: 10.1007/s00604-014-1341-3
J. Cao, D. Kürsten, K. Krause, E. Kothe, K. Martin, M. Roth and J.M. Köhler, “Application of Micro-Segmented Flow for Two-dimensional Characterization of the Combinatorial Effect of Zinc and Copper Ions on Metal-tolerant Streptomyces Strains”, Appl. Microbiol. Biotechnol. 2013, 97, 8923-8930, DOI: 10.1007/s00253-013-5147-8
J. Cao, D. Kürsten, S. Steffen, A. Knauer, P.M. Günther, J.M. Köhler, “Uncovering toxicological complexity by multi-dimensional screenings in micro segmented flow: Modulation of antibiotic interference by nano particles”, Lab Chip, 2012, 12 (3), 474-484, DOI:10.1039/c1lc20584f

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