Aktuelles

Am Mittwoch, den 20. Mai 2026, spricht um 15:00Uhr im Curie-Hörsaal,  

Prof. Anasuya Ganguly
Department of Biological Sciences
Birla Institute of Technology & Science, Pilani, India
www.bits-goa.ac.in

zum Thema:

„Scaffolds and Cells for Tissue Engineering of Pancreas and Skin“

Worldwide there is a shortage of vital organs for transplantation. To bridge the gap we need substitutes which can be made by tissue engineering, involving synthetic or biomaterials, cells and growth factors cross-linked together to synthesize a functional scaffold for repair or replacement of non-functional organs.

Our study focuses on synthesizing agarose composites embedded with chitosan-coated silver nanoparticles using glutaraldehyde as the cross-linker. The scaffold was characterized by UV-visible spectroscopy, XRD, FTIR, TGA, SEM, DMA, time of degradation, in-vitro cell viability, broad spectrum anti-bacterial activity, hemocompatibility, showing enhanced biocompatibility and greater surface area for cell growth. We also could isolate mice pancreatic cells which secreted insulin for over 40 days.

Similarly we tried composites of Bacillus megaterium H16 derived poly-3-hydroxybutyrate in making scaffolds for skin tissue engineering

INSTITUTSKOLLOQUIUM

des Instituts für Chemie und Biotechnik

Am Mittwoch, den 6. Mai 2026, spricht um 15:00Uhr im Curie-Hörsaal,  

Herr Prof. Dr. Danny Porath
Institut of Chemistry
Center for Nanoscience and Nanotechnology and Casali Center for Applied Chemistry
The Hebrew University of Jerusalem, Israel

zum Thema: „Charge Transport in DNA: From Fundamental Insights to Ultra-Sensitive Detection“

Abstract:

The ability to recognize and manipulate the DNA double helix opens new opportunities for molecular electronics. Our recent work (Nature Nanotechnology, 2020) demonstrated a breakthrough in measuring charge transport in DNA in a unique nanoscale configuration. This discovery is not only fundamental for understanding electrical properties in DNA but also holds broad implications for molecular electronics.

Beyond its fundamental scientific value, this insight lays the foundation for the development of ultra-sensitive, label-free DNA and RNA detection methods. Such advancements are particularly crucial for early cancer diagnosis, pathogen identification, emergency medicine, and pandemic preparedness, as seen in the case of COVID-19.

In this seminar, I will present our approach to probing charge transport in DNA and discuss how we are leveraging this phenomenon for next-generation molecular detection technologies.

References

[1] "Direct measurement of electrical transport through DNA molecules", Danny Porath, Alexey Bezryadin, Simon de Vries and Cees Dekker, Nature 403, 635 (2000).

[2] "Charge Transport in DNA-based Devices", Danny Porath, Rosa Di Felice and Gianaurelio Cuniberti, Topics in Current Chemistry Vol. 237, pp. 183-228 Ed. Gary Shuster. Springer Verlag, 2004.

[3] "Long-range charge transport in single G4-DNA molecules", Gideon I. Livshits et. al., Nature Nanotechnology 9, 1040 (2014).

[4] “Advances in Synthesis and Measurement of Charge Transport in DNA-Based Derivatives”. R. Zhuravel, A. Stern, N. Fardian‐Melamed, G. Eidelshtein, L. Katrivas, D. Rotem, A. Kotlyar and D. Porath, Advanced Materials 30, 1706984 (2018).

[5] "Backbone charge transport in double-stranded DNA", R. Zhuravel et. al., Nature Nanotechnology, 15(10), 836 (2020).

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