Modeling of single-walled carbon nanotube binding to nitric oxide synthase and guanylate cyclase molecular structures. - In: Neurophysiology, ISSN 1573-9007, Bd. 52 (2020), 2, S. 110-115
Previously, we have demonstrated that water dispersible single-walled carbon nanotubes (SWCNTs) may be used in low therapeutic doses in antihypertensive therapy as promising agents capable of activating constitutive nitric oxide synthase (NOS) in spontaneously hypertensive rats, thus increasing the NO production in central and peripheral elements of the cardiovascular system [1]. Here we confirm this effect by docking and molecular dynamics simulations, clearly showing that SWCNTs may interact with NOS and guanylate cyclase molecular structures.
https://doi.org/10.1007/s11062-020-09859-0
Systemic administrations of water-dispersible single-walled carbon nanotubes: activation of NOS in spontaneously hypertensive rats. - In: Neurophysiology, ISSN 1573-9007, Bd. 52 (2020), 2, S. 101-109
Priority data have been obtained on the effects of repeated systemic administrations of water-dispersible single-walled carbon nanotubes (SWCNTs) to spontaneously hypertensive rats with respect to constitutive NO-synthase (cNOS). As is known, NO is an inhibitory transmitter in the cardiovascular system. It was found that the systemic (i.p., subcutaneous, and i.m.) introductions of SWCNTs during two weeks resulted in considerable elevations of the NO2- level (a marker of NO bioavailability) in the blood of experimental hypertensive animals. Thus, SWCNTs may be used in the future for antihypertensive therapy as a novel agent capable of activating cNOS and, thus, increasing the NO production in central and peripheral elements of the cardiovascular system.
https://doi.org/10.1007/s11062-020-09858-1
Programmable multiple plasmonic resonances of nanoparticle superlattice for enhancing photoelectrochemical activity. - In: Advanced functional materials, ISSN 1616-3028, Bd. 30 (2020), 48, 2005170, insges. 10 S.
https://doi.org/10.1002/adfm.202005170
Square roots of H-nonnegative matrices. - Ilmenau : Technische Universität Ilmenau, Institut für Mathematik, 2020. - 1 Online-Ressource (24 Seiten). - (Preprint ; M20,01)
https://nbn-resolving.org/urn:nbn:de:gbv:ilm1-2020200426
C60 fullerene governs doxorubicin effect on metabolic profile of rat microglial cells in vitro. - In: Molecular pharmaceutics, ISSN 1543-8392, Bd. 17 (2020), 9, S. 3622-3632
Im Titel ist "60" tiefgestellt
Background: C60 fullerenes and their derivatives are actively investigated for the use in neuroscience. Applications of these nanoscale materials require the examination of their interaction with different neural cells, especially with microglia, because these cells, like other tissue resident phagocytes, are the earliest and most sensitive responders to nanoparticles. The aim of this study was to investigate the effect of C60 fullerene and its nanocomplex with doxorubicin (Dox) on the metabolic profile of brain-resident phagocytes - microglia - in vitro. Methods: Resting microglial cells from adult male Wistar rats were used in experiments. Potential C60 fullerene targets in microglial cells were studied by computer simulation. Microglia oxidative metabolism and phagocytic activity were examined by flow cytometry. Griess reaction and arginase activity colorimetric assay were used to explore arginine metabolism. Results: C60 fullerene when used alone did not influence microglia oxidative metabolism and phagocytic activity but shifted arginine metabolism toward the decrease of NO generation. Complexation of C60 fullerene with Dox (C60-Dox) potentiated the ability of the latter to stimulate NO generation. Conclusion: The capability of C60 fullerenes used alone to cause anti-inflammatory shift of microglia arginine metabolism makes them a promising agent for the correction of neuroinflammatory processes involved in neurodegeneration. The potentiating action of C60 fullerene on the immunomodulatory effect of Dox allows us to consider the C60 molecule as an attractive vehicle for this antitumor agent.
https://doi.org/10.1021/acs.molpharmaceut.0c00691
Evaluation of the biocompatibility of water-soluble pristine 60 fullerenes in rabbit. - In: BioNanoScience, ISSN 2191-1649, Bd. 10 (2020), 3, S. 721-730
Im Titel ist "60" tiefgestellt
C60 fullerenes have proved their therapeutic effects and efficacy by the results of countless experiments. For further usage of these nanoparticles, the systematic toxicological investigations are required. Blood compatibility should be studied for C60 fullerenes due to the potential blood contact. Currently, available data is not systematic and has not provided insights into possible side effects of C60 fullerenes on blood components. In this study, water-soluble pristine C60 fullerenes were tested in vitro to assess their biocompatibility in rabbit. The blood compatibility has been evaluated looking at the impact of C60 fullerenes on erythrocyte integrity, platelet aggregation, and some blood factors involved in coagulation. Our results revealed that C60 fullerenes cannot elicit hemolysis at studied concentrations and did not show any effect on coagulation process. C60 fullerenes in concentration-dependent manner increased ADP-dependent platelet aggregation and changed the key kinetic parameters of these processes. C60 fullerenes inhibited thrombin amidolytic activity but did not affect the activities of other studied coagulation factors. The prothrombotic property of C60 fullerenes could be the potential risk factor that leads to enhancement of vascular thrombosis. The ability of fullerene to inhibit thrombin activity is important for the pharmacological use of these carbon nanoparticles as anticoagulant agents.
https://doi.org/10.1007/s12668-020-00762-w
Structural analysis of sputtered Sc(x)Al(1-x)N layers for sensor applications. - In: Materials science and smart materials, (2020), S. 13-18
Rapid and controllable synthesis of nanocrystallized nickel-cobalt boride electrode materials via a mircoimpinging stream reaction for high performance supercapacitors. - In: Small, ISSN 1613-6829, Bd. 16 (2020), 39, 2003342, insges. 13 S.
Nickel-cobalt borides (denoted as NCBs) have been considered as a promising candidate for aqueous supercapacitors due to their high capacitive performances. However, most reported NCBs are amorphous that results in slow electron transfer and even structure collapse during cycling. In this work, a nanocrystallized NCBs-based supercapacitor is successfully designed via a facile and practical microimpinging stream reactor (MISR) technique, composed of a nanocrystallized NCB core to facilitate the charge transfer, and a tightly contacted Ni-Co borates/metaborates (NCBi) shell which is helpful for OH^- adsorption. These merits endow NCBNCBi a large specific capacity of 966 C g^-1 (capacitance of 2415 F g^-1) at 1 A g^-1 and good rate capability (633.2 C g^-1 at 30 A g^-1), as well as a very high energy density of 74.3 Wh kg^-1 in an asymmetric supercapacitor device. More interestingly, it is found that a gradual in situ conversion of core NCBs to nanocrystallized Ni-Co (oxy)-hydroxides inwardly takes place during the cycles, which continuously offers large specific capacity due to more electron transfer in the redox reaction processes. Meanwhile, the electron deficient state of boron in metal-borates shells can make it easier to accept electrons and thus promote ionic conduction.
https://doi.org/10.1002/smll.202003342
Investigation of epitaxial graphene via Raman spectroscopy: origins of phonon mode asymmetries and line width deviations. - In: Carbon, ISSN 1873-3891, Bd. 170 (2020), S. 666-676
In this work a comprehensive study is presented for the analysis of epitaxial graphene layers using Raman spectroscopy. A wide range of graphene types is covered, from defective/polycrystalline single layer graphene to multilayer graphene with low defect density. On this basis the influence of strain type, Fermi level and number of layers on the Raman spectrum of graphene is investigated. A detailed view on the 2D/G dispersion and the respective slopes of uniaxially and biaxially strained graphene is given and its implications on the asymmetry of the G peak analyzed. A linear dependency of the phonon mode asymmetry on uniaxial strain is presented in addition to the known Fermi level dependence. Additional impacts on the asymmetry are found to be arising from the defect density and transfer doping of adsorbates. The discovered transfer doping mechanism is contrary to pure phonon excitation through excitons and exhibits increasing asymmetry with increasing Fermi level. A new characteristic correlation between the 2D mode line width and the inverse I(D)/I(G) ratio is introduced that allows the determination of the strain type and layer number and explains the difference between Raman line widths of monolayer graphene on different substrates.
https://doi.org/10.1016/j.carbon.2020.07.016
A close step towards industrialized application of solar water splitting. - In: Journal of semiconductors, ISSN 2058-6140, Bd. 41 (2020), 9, 090401, S. 1-3
https://doi.org/10.1088/1674-4926/41/9/090401