25.03.2025

BreathObserver: TU Ilmenau launches research project with partners for the early detection of lung cancer

Mann hält Atemdiagnosegerät an seinem MundGeratherm Respiratory
TU Ilmenau has launched a research project to enable the early detection of lung cancer

A research consortium involving the TU Ilmenau has just launched a project to enable the early detection of lung cancer. With the help of a mobile respiratory diagnostic device, the human exhaled gas is to be analyzed with the aid of AI in order to detect signs of lung cancer earlier and more gently than before. The Federal Ministry of Education and Research is funding the three-year Breath-Observer project with 1.2 million euros.

Lung and bronchial cancer is one of the most common types of cancer in Germany, accounting for a fifth of all tumor diseases. However, the diagnostic procedures currently in use are invasive, i.e. they involve an intervention, i.e. penetrating the body, or radiological exposure and therefore entail risks of injury and infection. They are also very stressful and expensive for patients.

 

Mobile respiratory diagnostic device for the early detection of lung cancer

In the joint project BreathObserver, the project partners have set themselves the goal of developing a new type of medical diagnostic device for the direct analysis of human exhaled gas, which experts call exhalate. Exhaled breath contains a variety of gaseous substances whose composition is influenced by diseases, among other things. The researchers want to make use of this to identify biomarkers for cancer. Their ambitious goal: an innovative, mobile, non-invasive diagnostic device that detects biological characteristics in the air we breathe out at an early stage that reveal pathological signs of lung cancer. The analysis system, equipped with a disposable metal oxide gas sensor and in combination with established spirometric lung function measurement, should not only enable low-stress early detection of cancer with the help of artificial intelligence, but also the monitoring of the further course of the disease.

Strong research and development network with interdisciplinary expertise

Prof. Patrique Fiedler vor einem Schild mit der Aufschrift „TU Ilmenau, Bionikgebäude“TU Ilmenau/Eleonora Hamburg
Prof. Patrique Fiedler, BreathObserver project leader at TU Ilmenau, could imagine the use of the new respiratory diagnostic device in numerous other applications in the health sector

The BreathObserver network is coordinated by Geratherm Respiratory GmbH in Bad Kissingen in northern Bavaria, a leading developer and manufacturer of medical devices for lung diagnosis. The Institute for Biomedical Technology (BMTI) at TU Ilmenau will be involved in data processing and analysis of the sensor technology. UST Umweltsensortechnik GmbH in Thuringia, an established developer and manufacturer of innovative sensor technology for gases and temperature in particular, is responsible for the research work on the detection system's gas sensor technology. The University Hospital Jena will support and validate the project with medical expertise as well as research studies and comparisons with laboratory methods of gas analysis.

The exhalate analysis system could be used for a rapid initial cancer diagnosis and for follow-up monitoring in clinics and doctors' surgeries. But Prof. Patrique Fiedler, BreathObserver project manager at the TU Ilmenau and head of the Group of Data Analysis in the Life Sciences, is already thinking ahead:

"I could imagine extending our research work to numerous other applications in the health sector: With research results from the BreathObserver project, we could also detect lung diseases of an infectious nature in the future. And since the small device is intended to be cost-effective, I also see a wide range of potential applications in the subsequent medical device development phase."


Modular design enables a wide range of other applications

In fact, the research team has already considered other future uses for the modular and multimodal analysis system. The system consists of electronic components and sensors that provide the information for data processing and analysis. All individual components can be exchanged at a later date, thus enabling easy adaptation for other applications such as the detection of infectious diseases.

As the system has not just one, but several sensors with different measuring principles, parameters such as temperature, gas volume and pressure are measured in addition to the composition of the respiratory gas. This means that both the calibration of the sensors, i.e. checking their accuracy, and the quality assurance of the measurement can be continuously improved and any deviations in the measurement results can be precisely corrected.

 

Contact

Prof. Patrique Fiedler
Head of the Department of Data Analysis in the
Life Sciences
+49 3677 69-2865
patrique.fiedler@tu-ilmenau.de