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Jun.-Prof. Dr.-Ing. Patrique Fiedler
BMTI, Head of Data Analysis in Life Sciences
Jun.-Prof. Dr.-Ing. Patrique Fiedler
+49 3677 69 2865
Transcranial direct current stimulation protocols are often applied with a fixed parameter set to all subjects participating in an interventional study. This might lead to considerable effect variation in inhomogeneous subject groups or when transferring stimulation protocols to different age groups.
The aim of this study was to evaluate magnitude differences of the electric current density distribution on the gray matter surface in children, adolescent and adults in correlation with the individual volume conductor geometry.
We generated individual six compartment finite element models from structural magnetic resonance images and determined the skull thickness in the models as Euclidean distance between the surface of the cerebrospinal fluid compartment and outer skull boundary. For tDCS simulations, the resulting current density was analyzed on the gray matter surface.
Our results demonstrate higher cortical current density magnitudes in children compared to adults for a given tDCS current strength.
In conclusion, we underline the importance of age-dependent and individual models in tDCS simulations.
Alexander Hunold, Jens Haueisen, Christine M. Freitag, Michael Siniatchkin, Vera Moliadze:
Cortical current density magnitudes during transcranial direct current stimulation correlate with skull thickness in children, adolescent and young adults
Progress in Brain Research, Elsevier 2020, ISSN 0079-6123
https://authors.elsevier.com/a/1d7wHI6Wm7Egi
https://doi.org/10.1016/bs.pbr.2021.01.010
Contact: Alexander Hunold, Prof. Dr.‐Ing. Jens Haueisen