BIODIAGNOSTICS - Biological diagnostic tools using microsystems and supersensitive magnetic detection

 

Overview

Image 1: Measurement of magnetic nanoparticle phantoms at the Biomagnetic Centre of the FSU Jena Image 2: Reconstruction of the nanoparticle distribution from a phantom measurement

The objective of the proposed project is to develop new medical diagnostic tools based on the most sensitive detector technologies available today. A common denominator for the technologies is reading out the biological state in the magnetic domain. This will be accomplished by using both magnetic nanoparticles as substrates or tags for biological reactions and reading out the atomic nuclear spin. The latter technology is a development from the inductive readout in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). The technology used in this project is a pure magnetic field read-out system, which quite contrary to the inductive method has a sensitivity which is more or less independent of frequency and magnetic field down to very low fields. The several competing technologies will be benchmarked against each other with a model system consisting of biotin and streptavidine in order to gain a unique understanding of the differences and advantages with the different systems. To validate the concept(s), real diagnostic test will be done on in vitro detection of F1 antigen (y. pestis) Mycobacterium tuberculosis in urine samples and detection of Yersinia pestis F1 antigen in environmental samples (bio terrorism). Further to the validation, neuroimaging and instrumentation for diagnosis of neurological diseases will be investigated in vivo.

Project partners

  • Chalmers University of Technology, Sweden
  • Imego AB, Sweden
  • Karolinska Institute, Sweden
  • The Royal Institute of Technology, Sweden
  • Forschungzentrum Juelich, Germany
  • Juelicher SQUID GmbH, Germany
  • Senova GmbH, Jena, Germany
  • Physikalische Technische Bundesanstalt, Germany
  • Chemicell GmbH, Berlin, Germany
  • Friedrich-Schiller-Universität Jena, Germany
  • Micro-Sphere S.A., Switzerland
  • Royal Holloway University London, Great Britain
  • MIC/DTU, Denmark
Image 1: Project partners at the mid term review meeting in Berlin

Publications & patents

  •     Crevecoeur, G., Baumgarten, D., Steinhoff, U., Haueisen, J., Trahms, L., Dupré, L.: Advancements in Magnetic Nanoparticle Reconstruction Using Sequential. Activation of Excitation Coil Arrays Using Magnetorelaxometry. IEEE TRANSACTIONS ON MAGNETICS, VOL. 48, NO. 4, April 2012 1313 - 1316
  •     Eichardt,R., Baumgarten,D., Petkovic,B., Wiekhorst,F., Trahms,L., Haueisen,J.: Adapting source grid parameters to improve the condition of the magnetostatic linear inverse problem of estimating nanoparticle distributions. Medical & Biological Engineering & Computing, 50(10):1081-9, 2012
  •     Baumgarten, D., Haueisen J.: A Spatio-Temporal Approach for the Solution of the Inverse Problem in the Reconstruction of Magnetic Nanoparticle Distributions. IEEE Transactions on Magnetics, vol. 46, no. 8, August 2010: 3496-3499;
  •     Eichardt R, Haueisen J: Influence of Sensor Variations on the Condition of the Magnetostatic Linear Inverse Problem. IEEE Transactions on Magnetics, 46(8): 3449 - 3452, 2010
  •     Baumgarten D, Doering A: Registrierung von Aufnahmen des Augenhintergrundes zur Erstellung großflächiger Kompositionsaufnahmen. Biomed Tech, Vol. 52, Nr. 6, S. 365–374, 2007;
  •     Baumgarten D, Liehr M, Wiekhorst F, Steinhoff U, Münster P, Trahms L, Haueisen J: Magnetic Nanoparticle Imaging by means of Minimum Norm Estimates from Remanence Measurements. Accepted for publication in Med Biol Eng Comp, 2008;
  •     Baumgarten D, Steinhoff U, Haberkorn W, Wiekhorst F, Trahms L, Haueisen J: Minimum Norm and Multipole Based Algorithms for the Reconstruction of Magnetic Nanoparticle Distributions in Biological Tissue. Submitted to the International on Biomagnetism 2008 (BIOMAG08), Aug 25-29, Sapporo, Japan, 2008;
  •     Baumgarten D, Liehr M, Wiekhorst F, Steinhoff U, Münster P, Trahms L, Haueisen J: Estimation of Magnetic Nanoparticle Distributions with a Minimum Norm Approach: Determination of relevant Parameters. Submitted to the International on Biomagnetism 2008 (BIOMAG08), Aug 25-29, Sapporo, Japan, 2008;
  •     Baumgarten D, Liehr M, Haueisen J: Magnetic Imaging of Nanoparticles using Minimum Norm Algorithms. Joint Meeting of the 6th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart and the International Conference on Functional Biomedical Imaging, Zhejiang University Hangzhou (China), 12.-14.10.2007;
  •     Baumgarten D, Liehr M, Haueisen J: Magnetic Imaging of Nanoparticles using Minimum Norm Algorithms. In Proceedings 41. Jahrestagung der Deutschen Gesellschaft für Biomedizinische Technik (DGBMT) im VDE, Aachen, Deutschland, 26.-29.09.2007;
  •     Baumgarten D, Doering A, Trost M: Composition of Wide Field Fundus Images Using a Non-Linear Registration Technique. ARVO’s 2007 Annual Meeting, Fort Lauderdale (Florida), 06.-10.05.2007;
  •     Baumgarten, D., Doering, A., Trost, M.: Registrierung von Aufnahmen des Augenhintergrundes zur Erstellung großflächiger Kompositionsaufnahmen. Workshop Bildverarbeitung für die Medizin, München, Deutschland, 2007;
  •     Baumgarten, D.: Registrierung von Aufnahmen des Augenhintergrundes zur Erstellung großflächiger Kompositionsaufnahmen. Diplomarbeit TU Ilmenau, 2006

Sponsorship