MAMUD - Model based analysis of multimodal data under uncertainties

 

Overview

Why?

Medical and technical diagnostic devices produce growing amounts of data. The combination and joint evaluation of data from different measurement methods (multimodal data) offers additional information for the early detection of various diseases.

With the growing amount of data, the uncertainty in decision processes increases. If these uncertainties are not considered sufficiently, the results of the data analysis can be distorted. This can possibly lead to diagnostic errors.

What?

Development of novel analysis methods for multimodal data.
Consideration and minimization of occurring uncertainties.
Demonstration of the effectivity of the newly developed methods in medical and technical applications.
Protection of vision for a self-determined life by more reliable multimodal diagnostics of ocular diseases.

How?

 

Foundation companies

Sponsorship

Publications

2012

  • SALEH, K., UNGER, V., DIETZEL, A., GROßJOHANN, R., JÜRGENS, C., TOST, F., and HAUEISEN, J. “Evaluation of a novel method to measure the intraocular pressure based on a mechanical eye model”, 46. Jahrestagung der Deutsche Gesellschaft für Biomedizinische Technik (DGBMT) , Jena, 16.-19. September 2012. (accepted
  • S. Schramm, B.-U. Seifert, J. Haueisen, P. Schikowski, J. Prehl, A. Kaeding, und K. S. Kunert, „Comparative Investigation in Stray Light Measurement in the Human Eye“, in Proceedings BMT 2012, Jena, 2012, S. 1862–278X.
  • M. Peter, R. Kammel, R. Ackermann, S. Schramm, B.-U. Seifert, K. Frey, M. Blum, S. Nolte, und K. S. Kunert, „Analysis of optical side-effects of fs-laser therapy in human presbyopic lens simulated with modified contact lenses“, Graefes Arch. Clin. Exp. Ophthalmol., Feb. 2012.
  • Erteilte Patente: B.-U. Seifert, S. Schramm, und J. Haueisen, „Vorrichtung und Verfahren zur simultanen Erfassung von Aberrationen und Streulichtkenngrößen eines optischen System“, DE 10 2011 102 176 A1, 22-Nov-2012. 
  • Silbermedaille des Salon Interenational des Inventions Genève 2012
  • Erteilte Patente: SALEH, K., UNGER, V., DIETZEL, A. , HAUEISEN, J., HEYDENREICH, D., GLEI, H., MÜLLER, J., GROßJOHANN, R., JÜRGENS, C., TOST, F . "Vorrichtung und Verfahren zur automatisierten Bestimmung des Intraokulardruckes" . DE 102011015178 B3(erteilt am 03.05.2012)

2011

  • Baumgarten, D.: Computational and experimental investigations on the imaging of magnetic nanoparticles based on magnetorelaxometry and minimum norm estimations for biomedical applications, DISSERTATION, Shaker-Verlag, 2011
  • S. Schramm, P. Schikowski, M. Reder, K. Kunert, und B. U. Seifert, „Plausibility of Stray Light Measurement with a modified Wavefront Analyzer“, ARVO Meet. Abstr., Bd. 52, Nr. 6, S. 6217, Apr. 2011.
  • S. Schramm und B.-U. Seifert, „Streulichtmessung mit Hartmann-Shack-Sensor am Auge“, in DGaO-Proceedings 2011, 2011.
  • B. U. Seifert, P. Schikowski, K. S. Kunert, M. Reder, und S. Schramm, „Enhanced Feature Segmentation and Data Extraction in Pentacam Scheimpflug Images“, ARVO Meet. Abstr., Bd. 52, Nr. 6, S. 5707, Apr. 2011.
  • K. S. Kunert, M. Nennstiel, M. Blum, S. Schramm, B.-U. Seifert, P. Schikowski, J. Prehl, und M. Reder, „Presbyopia is the First Stage of Nuclear Cataract-Analysis of Forward and Backward Scattered Straylight in the Presbyopic Human Lens“, ARVO Meet. Abstr., Bd. 52, Nr. 6, S. 826, Apr. 2011.
  • M. P. Reder, M. Blum, S. Schramm, B. U. Seifert, R. Ackermann, R. Kammel, S. Nolte, und K. S. Kunert, „Analysis of Optical Side Effects of fs-Laser Therapy in the Human Presbyopic Lens Simulated With Modified Contact Lenses“, ARVO Meet. Abstr., Bd. 52, Nr. 6, S. 6215, Apr. 2011.
  • Haueisen, J., Dietzel, A., Liehr, M., Weiser, Th., Elsarnagawy, T., Bellemann ME.: Bioelectric and biomagnetic measurements are differentially sensitive to spiral currents. Biomedizinische Technik, 56(5): 283-289, 2011
  • Saleh, K., Unger, V., Dietzel, A., Großjohann, R., Jürgens, C., Tost, F., Haueisen, J.: Mechanical eye model for evaluation of intraocular pressure measuring under consideration of the biomechanical characteristics., 10th International Workshop on Biomedical Engineering, Kos Island, Greece, 05-07 October, 2011;
  • Dietzel, A., Nagel, E.: Calculation of Optic Nerve Head Parameters based on OCT data. Symposium OCTI2011, Ilmenau, 12-14 September, 2011;
  • Dietzel, A., Walz, K., Nagel, E.: Automatische Segmentierung retinaler Schichten in OCTDaten und deren Genauigkeit. 109. DOG Kongress, 29.09.-02.10. 2011, Estrel Hotel, Berlin, 2011;
  • Unger, V., Saleh, K., Dietzel, A., Heydenreich, D., Großjohann, R., Jürgens, C., Tost, F., Haueisen, J.: Neues Verfahren zur Augeninnendruckmessung unter Berücksichtigung biomechanischer Eigenschaften der Kornea. 45. Jahrestagung der DGBMT, Freiburg, 27-30 September, 2011;
  • Silbermedaille bei der IENA 2011

2010

  • Baumgarten, D., Haueisen J.: A Spatio-Temporal Approach for the Solution of the Inverse Problem in the Reconstruction of Magnetic Nanoparticle Distributions. IEEE Transactions on Magnetics, vol. 46, no. 8, August 2010: 3496-3499;
  • S. Schramm, B.-U. Seifert, und D. Link, „Influence of the Shell Structure of the Human Lens on Accommodation Using Ray Tracing“, ARVO Meet. Abstr., Bd. 51, Nr. 5, S. 790, Apr. 2010.
  • B.-U. Seifert, S. Schramm, P. Bessler, P. Schikowski, und K. S. Kunert, „Clinical Validation of a Modified Wavefront Analyzer - Preliminary Results“, ARVO Meet. Abstr., Bd. 51, Nr. 5, S. 3948, Apr. 2010.
  • Dietzel, A., Haueisen, J.: Coregistration of Fluorescence Lifetime Imaging (FLIM) and Optical Coherence Tomography (OCT). ARVO 2010 Annual Meeting, May 2 - May 6, 2010, Fort Lauderdale/Florida, USA;
  • Dietzel, A., Klemm, M., Nagel, E., Schweitzer, D., Haueisen, J.: Reproducibility of Fluorescence Lifetime Imaging (FLIM) at the Human Retina based on Multi Exponential Component Fit. In G.K.Lang and S.J.Ryan, editors, World Ophthalmology Congress 2010, Berlin;
  • Klemm, M., Dietzel, A., Nagel, E., Schweitzer, D., Graichen, U., Haueisen, J.: Reproducibility of Ophthalmic Lifetime Mapper measurements. Symposium FLIM2010, Ilmenau, 2010;
  • Klemm, M., Dietzel, A., Nagel, E., Schweitzer, D., Graichen, U., Haueisen, J.: Statistical Analysis of Reproducibility of Fluorescence Decay Histograms at the Fundus. Investigative Ophthalmology & Visual Science 51:2293, ARVO, Fort Lauderdale (USA), 2010;

2009

  • Klemm, M., Dietzel, A.: Bildgebung und Spectral Imaging an der Netzhaut. 5. NEMO-SpectroNet Kollaboration Forum;

2008

  • Baumgarten D, Liehr M, Wiekhorst F, Steinhoff U, Münster P, Trahms L, Haueisen J: Magnetic Nanoparticle Imaging by means of Minimum Norm Estimates from Remanence Measurements. Accepted for publication in Med Biol Eng Comp, 2008
  • Baumgarten D, Steinhoff U, Haberkorn W, Wiekhorst F, Trahms L, Haueisen J: Minimum Norm and Multipole Based Algorithms for the Reconstruction of Magnetic Nanoparticle Distributions in Biological Tissue. Submitted to the International on Biomagnetism 2008 (BIOMAG08), Aug 25-29, Sapporo, Japan, 2008;
  • Baumgarten D, Liehr M, Wiekhorst F, Steinhoff U, Münster P, Trahms L, Haueisen J: Estimation of Magnetic Nanoparticle Distributions with a Minimum Norm Approach: Determination of relevant Parameters. Submitted to the International on Biomagnetism 2008 (BIOMAG08), Aug 25-29, Sapporo, Japan, 2008;

2007

  • Baumgarten D, Doering A: Registrierung von Aufnahmen des Augenhintergrundes zur Erstellung großflächiger Kompositionsaufnahmen. Biomed Tech, Vol. 52, Nr. 6, S. 365–374, 2007;
  • Baumgarten D, Liehr M, Haueisen J: Magnetic Imaging of Nanoparticles using Minimum Norm Algorithms. Joint Meeting of the 6th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart and the International Conference on Functional Biomedical Imaging, Zhejiang University Hangzhou (China), 12.-14.10.2007;
  • Baumgarten D, Liehr M, Haueisen J: Magnetic Imaging of Nanoparticles using Minimum Norm Algorithms. In Proceedings 41. Jahrestagung der Deutschen Gesellschaft für Biomedizinische Technik (DGBMT) im VDE, Aachen, Deutschland, 26.-29.09.2007;
  • Baumgarten D, Doering A, Trost M: Composition of Wide Field Fundus Images Using a Non-Linear Registration Technique. ARVO’s 2007 Annual Meeting, Fort Lauderdale (Florida), 06.-10.05.2007;
  • Baumgarten, D., Doering, A., Trost, M.: Registrierung von Aufnahmen des Augenhintergrundes zur Erstellung großflächiger Kompositionsaufnahmen. Workshop Bildverarbeitung für die Medizin, München, Deutschland, 2007;

2006

  • Baumgarten, D.: Registrierung von Aufnahmen des Augenhintergrundes zur Erstellung großflächiger Kompositionsaufnahmen. Diplomarbeit TU Ilmenau, 2006

2005

  • H. Hoyer, C. Scheungraber, R. Kühne-Heid, K. Teller, C. Greinke, S. Leistritz, B. Ludwig, M. Dürst, and A. Schneider, "Cumulative 5-year diagnoses of CIN2, CIN3 or cervical cancer after concurrent high-risk HPV and cytology testing in a primary screening setting," International Journal of Cancer, vol. 116, pp. 136-143, 2005.

2002

  • C. Scheungraber, B. Müller, C. Köhler, M. Possover, S. Leistritz, A. Schneider, and M. Dürst, "Detection of disseminated tumor cells in patients with cervical cancer," Journal of Cancer Research and Clinical Oncology, vol. 128, pp. 329-335, 2002.

2001

  • C. Backsch, N. Wagenbach, M. Nonn, S. Leistritz, E. Stanbridge, A. Schneider, and M. Dürst, "Microcell-mediated transfer of chromosome 4 into HeLa cells suppresses telomerase activity," Genes Chromosomes & Cancer, vol. 31, pp. 196-198,2001
  • M. Hammer, S. Leistritz, L. Leistritz, and D. Schweitzer, "Light paths in retinal vessel oxymetry," IEEE Transactions on Biomedical Engineering, vol. 48, pp. 592-598, 2001.

2000

  • A. Schneider, H. Hoyer, B. Lotz, S. Leistritz, R. Kühne-Heid, I. Nindl, B. Müller, J. Haerting, and M. Dürst, "Screening for high-grade cervical intra-epithelial neoplasia and cancer by testing for high-risk HPV, routine cytology or colposcopy," International Journal of Cancer, vol. 89, pp. 529-534, 2000

1997

  • P. Putsche, L. Leistritz, and S. Leistritz, "Use of the Hilbert operator for determining absorption differences between retinal blood vessels and their surroundings," Biomedizinische Technik, vol. 42 Suppl, pp. 426-427, 1997
  • P. Putsche, L. Leistritz, S. Leistritz, H. Witte, and M. Hammer, "Experimental study of the application of the Hilbert operator as a signal preprocessing method for the measurement of oxygen saturation in retinal vessels," Biomedizinische Technik, vol. 42 Suppl, pp. 332-336, 1997
  • M. Hammer, S. Leistritz, L. Leistritz, D. Schweitzer, E. Thamm, and K. H. Donnerhacke, "Monte-Carlo simulation of retinal vessel profiles for the interpretation of in vivo oxymetric measurements by imaging fundus reflectometry," Medical Applications of Lasers in Dermatology, Ophthalmology, Dentistry, and Endoscopy, Proceedings Of, vol. 3192, pp. 211-218, 1997