The lecture is online available in Moodle.
Course content:
The interaction between drugs and the organism, switching on active ingredients, active ingredient target classes / receptors and enzymes, ADME-Tox, pharmacokinetics, pharmacodynamics, lead structure optimization, combinatorial chemistry, assays, active ingredient screening HTS, the development process, examples from different areas of application . The lectures cover general and special pharmaceutical / medicinal chemistry as well as biotechnology. In this context, the basics of drug chemistry (ligand-receptor interactions, qualitative and quantitative structure-activity relationships, computer-aided methods, drug design (structure and function of the most important biological target molecules) are imparted, as well as deeper insights into current drug chemistry using selected substance classes and areas of indication This concerns the chemistry (synthesis, chemical properties) of the active substances concerned, their molecular mechanisms of action and structure-action relationships, the underlying pharmacotherapeutic concepts, desired and important adverse drug effects as well as the biotransformation of medicinal substances