Analysis of cell spreading mechanisms

Osteoblasten auf TIiiba Heiligenstadt
Osteoblasten auf TIi

Cell spreading on substrate surfaces is associated with the reorganization of the intracellular actin network. By analyzing the focal surfaces mediating cell adhesion, it was possible to detect different forces involved in the active forward movement of cells versus retraction. Fluorescence multiple labeling of actin filaments and enzymes can be used to elucidate the molecular basis of the underlying different processes.

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