Analysis of cell spreading mechanisms
iba HeiligenstadtCell spreading on substrate surfaces is associated with the reorganization of the intracellular actin network. By analyzing the focal surfaces mediating cell adhesion, it was possible to detect different forces involved in the active forward movement of cells versus retraction. Fluorescence multiple labeling of actin filaments and enzymes can be used to elucidate the molecular basis of the underlying different processes.
Publications within this project:
- Ramijan Carmiol A.K., Ultee E., Willemse J.J., Zhang Z., Wondergem A.J., Meij A. van der, Heinrich D.M., Briegel A., Wezel G.P. van & Claessen D. (2018), Stress-induced formation of cell wall-deficient cells in filamentous actinomysetes, NatureCommunications9: 5164.article in journal: refereed
- Wel C.M. van der, Bossert N., Mank Q.J., Winter M.G.T., Heinrich D.M. & Kraft D.J. (2017), Surfactant-free colloidal particles with specific binding affinity, LANGMUIR33: 9803-9810.article in journal: refereed
- Wel C.M. van der, Heinrich D.M. & Kraft D.J. (2017), Microparticle assembly pathways on lipid membranes, BiophysicalJournal 113(5): 1037-1046.article in journal: refereed
- Heinrich D.M., Ecke M., Jasnin M., Engel U. & Gerisch G. (2014), Reversible membrane pearling in live cells upon destruction of the actin cortex, BiophysicalJournal 106: 1079-1091.article in journal: refereed