Conference papers

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Nycz, Julia; Link, Dietmar; Klemm, Matthias; Klee, Sascha; Haueisen, Jens
Characterization of a new fluorescence lifetime imaging ophthalmoscope. - In: Acta ophthalmologica, ISSN 1755-3768, Bd. 102 (2024), S279, insges. 1 S.

Aims/Purpose: Fluorescence lifetime imaging ophthalmoscopy (FLIO) allows in vivo measurement of autofluorescence intensity decays of endogenous fluorophores in the ocular fundus. So far, only devices from Heidelberg Engineering based on the Spectralis system have been used in FLIO research. Here, we present and characterize a new FLIO device based on the RETImap system from Roland Consult. Methods: The device is based on a confocal scanning laser ophthalmoscope (35˚ field, 512 × 512 px). A ps diode laser (BDL-SMN 473 nm, Becker & Hickl GmbH, Berlin, Germany) excites autofluorescence. The fluorescence photons are split into a short (498-560 nm, SSC) and a long (560-720 nm, LSC) spectral channel (one HPM-100-40 detector [Becker & Hickl GmbH] each) and are detected by time-correlated single photon counting (SPC-160, Becker & Hickl GmbH). We determined the maximum laser power (ILT2400, International Light Technologies, Inc. Peabody, MA, USA) and analysed the instrument's behaviour at three different laser power levels (150 μW, 200 μW and max.) in terms of laser spectrum (CAS140CT, Instrument Systems GmbH, Munich, Germany) and instrument response function (IRF). The IRF was determined using a 25 μM Eosin Y solution, mixed with a 5 M solution of potassium iodide, placed in a flat cuvette (110-OS, Hellma GmbH & Co. KG, Müllheim, Germany) in front of the objective lens of the FLIO device. Fluorescence measurements of approximately 1-min duration were performed three times for all three laser powers. The IRF and the full width at half maximum (FWHM) were calculated using FLIMX software (www.flimx.de). Results: The max. laser power was 280 μW. The peak wavelengths of the laser spectra were 467.6 (150 μW), 467.9 (200 μW) and 468.0 nm (280 μW). IRF FWHM in SSC were 298.6 ± 1.1 ps (150 μW), 341.0 ± 2.5 ps (200 μW) and 347.5 ± 6.0 ps (280 μW). In LSC, the IRF FWHM were 290.4 ± 3.8 ps (150 μW), 344.0 ± 3.4 ps (200 μW) and 358.8 ± 1.3 ps (280 μW). Results are mean ± standard deviation. Conclusions: A new fluorescence lifetime imaging ophthalmoscope has been characterized. The device offers a high laser power for fluorescence excitation, a large field of view, a high spatial resolution, and a sufficiently high time resolution. Thus, it is suitable for fluorescence lifetime studies.



https://doi.org/10.1111/aos.15921
Fiedler, Patrique; Komosar, Milana; Warsito, Indhika Fauzhan; Bernhard, Maria Anne; Haueisen, Jens
Comfortable dry EEG using Flower electrodes. - In: Biomedical engineering, ISSN 1862-278X, Bd. 68 (2023), S. 221

https://doi.org/10.1515/bmte-2023-2001
Blum, Maren-Christina; Oppermann, Hannes; Leydolph, Lilly; Hetterscheidt, Johanna Thea; Nya, Armèle Tatiana; Hunold, Alexander; Haueisen, Jens
Pilot study on the effect of a transocular alternating current stimulation on the steady-state pattern-reversal electroretinogram. - In: Biomedical engineering, ISSN 1862-278X, Bd. 68 (2023), S. 212

https://doi.org/10.1515/bmte-2023-2001
Oppermann, Hannes; Thelen, Antonia; Haueisen, Jens
Amplitude fluctuations in the averaged photic driving in the electroencephalogram correspond to burst occurrence in single trials. - In: Biomedical engineering, ISSN 1862-278X, Bd. 68 (2023), S. 209

https://doi.org/10.1515/bmte-2023-2001
Wegert, Laureen; Hunold, Alexander; Ziolkowski, Marek; Lange, Irene; Kalla, Tim; Haueisen, Jens
Detailed anatomical neck model for electromagnetic simulations. - In: Biomedical engineering, ISSN 1862-278X, Bd. 68 (2023), S. 181

https://doi.org/10.1515/bmte-2023-2001
Kügler, Niklas; Omira, Ahmad; Haueisen, Jens; Schweser, Ferdinand; Jochmann, Thomas
Exploring the orientation dependency of nondipolar frequency shifts in magnetic resonance imaging: an approach to unveil chemical exchange and tissue microstructure in the brain. - In: Biomedical engineering, ISSN 1862-278X, Bd. 68 (2023), S. 166

https://doi.org/10.1515/bmte-2023-2001
Jochmann, Thomas; Jakimovski, Dejan; Hametner, Simon; Zivadinov, Robert; Haueisen, Jens; Schweser, Ferdinand
Deep learning enables a novel magnetic resonance imaging contrast that unveils chemical and microstructural brain tissue changes through nondipolar larmor frequency shifts. - In: Biomedical engineering, ISSN 1862-278X, Bd. 68 (2023), S. 160

https://doi.org/10.1515/bmte-2023-2001
Omira, Ahmad; Kügler, Niklas; Haueisen, Jens; Schweser, Ferdinand; Jochmann, Thomas
Mapping the anisotropy of tissue magnetic susceptibility from single-orientation magnetic resonance imaging. - In: Biomedical engineering, ISSN 1862-278X, Bd. 68 (2023), S. 156

https://doi.org/10.1515/bmte-2023-2001
Jochmann, Thomas; Rabold, Jeannette; Jochmann, Elisabeth; Fiedler, Patrique; Haueisen, Jens
Real-time smartphone-assisted EEG electrode localization and augmented reality application. - In: Biomedical engineering, ISSN 1862-278X, Bd. 68 (2023), S. 153

https://doi.org/10.1515/bmte-2023-2001
Zahn, Diana; Landers, Joachim; Diegel, Marco; Salamon, Soma; Stihl, Andreas; Schacher, Felix; Wende, Heiko; Dellith, Jan; Dutz, Silvio
Cobalt ferrite nanoparticles as thermal markers on lateral flow assays. - In: Biomedical engineering, ISSN 1862-278X, Bd. 68 (2023), S. 126

https://doi.org/10.1515/bmte-2023-2001